Photodynamic therapy of cancer: An update

Agostinis, Patrizia; Berg, Kristian; Cengel, Keith A.; Foster, Thomas H.; Girotti, Albert W.; Gollnick, Sandra O.; Hahn, Stephen M.; Hamblin, Michael R.; Juzeniene, Asta; Kessel, David; Korbelik, Mladen; Moan, Johan; Mróz, Paweł; Nowis, Dominika; Piette, Jacques; Wilson, Brian C.; Gołąb, Jakub

doi:10.3322/caac.20114

reviewCA A Cancer Journal for CliniciansMay 26, 2011DIAMOND OA

Photodynamic therapy of cancer: An update

PAPatrizia Agostinis KBKristian Berg KAKeith A. Cengel THThomas H. Foster AWAlbert W. Girotti

Catholic University of America · KU Leuven · +21 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible…

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Topics & keywords

Topics

Keywords

Medicine
Photodynamic therapy
Cancer
Toxicity
Cancer treatment
Therapeutic effect
Cancer research
Oncology

UN Sustainable Development Goals

Good health and well-being

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