Nanog Is the Gateway to the Pluripotent Ground State
Wellcome/MRC Cambridge Stem Cell Institute · University of Cambridge · +3 more institutions
Abstract
Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present evidence that the homeodomain protein Nanog mediates acquisition of both embryonic and induced pluripotency. Production of pluripotent hybrids by cell fusion is promoted by and dependent on Nanog. In transcription factor-induced molecular reprogramming, Nanog is initially dispensable but becomes essential for dedifferentiated intermediates to transit to ground state pluripotency. In the embryo, Nanog specifically demarcates the nascent epiblast, coincident with the domain of X chromosome…
Citation impact
- FWCI
- 40.10
- Percentile
- 100%
- References
- 62
Authors
10- JSJosé SilvaCorresponding
Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge
- JNJennifer Nichols
Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge
- TWThorold W. Theunissen
Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge
- GGGe Guo
Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge
- ALAnouk L. van Oosten
Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge
Topics & keywords
- Epiblast
- Homeobox protein NANOG
- Reprogramming
- Biology
- Rex1
- Cell biology
- Nanog Homeobox Protein
- Induced pluripotent stem cell