MRI characteristics of neuromyelitis optica spectrum disorder
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Abstract
Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti-aquaporin-4 antibody diagnostic biomarker for NMO enabled recognition of more diverse clinical spectrum of manifestations. Brain MRI abnormalities in patients seropositive for anti-aquaporin-4 antibody are common and some may be relatively unique by virtue of localization and configuration. Some seropositive patients present with brain involvement during their first attack and/or continue to relapse in the same location without optic nerve and spinal cord involvement. Thus, characteristics of brain abnormalities in such…
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63Topics & keywords
Topics
Keywords
- Neuromyelitis optica
- Multiple sclerosis
- Medicine
- Spectrum disorder
- Spinal cord
- Aquaporin 4
- Optic nerve
- Disease
UN Sustainable Development Goals
- Industry, innovation and infrastructure
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