The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
University of Cambridge · Wellcome Trust · +2 more institutions
Abstract
It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E(2) (PGE(2)) have key roles in influencing the development of colorectal cancer. Deregulation of the COX-2/PGE(2) pathway appears to affect colorectal tumorigenesis via a number of distinct mechanisms: promoting tumour maintenance and progression, encouraging metastatic spread, and perhaps even participating in tumour initiation. Here, we review the role of COX-2/PGE(2) signalling in colorectal tumorigenesis and highlight its ability to influence the hallmarks of cancer--attributes defined by Hanahan and Weinberg as being requisite for tumorigenesis. In addition, we consider…
Citation impact
- FWCI
- 65.79
- Percentile
- 100%
- References
- 168
Authors
7- AGAlexander Greenhough
University of Cambridge, Wellcome Trust, University of Bristol, Wellcome/Cancer Research UK Gurdon Institute
- HSH Smartt
Wellcome Trust, University of Cambridge, Wellcome/Cancer Research UK Gurdon Institute, University of Bristol
- AEAlice E. Moore
Wellcome Trust, University of Bristol, University of Cambridge, Wellcome/Cancer Research UK Gurdon Institute
- HRH R Roberts
University of Bristol, University of Cambridge, Wellcome Trust, Wellcome/Cancer Research UK Gurdon Institute
- ACAnn C. Williams
Wellcome Trust, University of Cambridge, Wellcome/Cancer Research UK Gurdon Institute, University of Bristol
Topics & keywords
- Carcinogenesis
- Cellular adaptation
- Cancer research
- Colorectal cancer
- Tumor microenvironment
- Biology
- Prostaglandin
- Cancer
- Good health and well-being