Size‐Dependent Endocytosis of Nanoparticles

The cellular uptake of nanoparticles by living cells is predicted to be strongly size-dependent, according the thermodynamic analysis, and an optimal particle radius of ∼ 25–30 nm at which the cellular uptake reaches a maximum of several thousand is shown to exist. The theoretical prediction provides valuable guidance for the rational design of nanoparticle-based drug-delivery systems.

• NS
  National Science Foundation
• NI
  National Institutes of Health
• NH
  National Heart, Lung, and Blood Institute
• DO
  Division of Civil, Mechanical and Manufacturing Innovation