CD45: A Critical Regulator of Signaling Thresholds in Immune Cells
Howard Hughes Medical Institute · University of California, San Francisco
Abstract
Regulation of tyrosine phosphorylation is a critical control point for integration of environmental signals into cellular responses. This regulation is mediated by the reciprocal actions of protein tyrosine kinases and phosphatases. CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in antigen receptor signal transduction and lymphocyte development. It is now known that CD45 also modulates signals emanating from integrin and cytokine receptors. Recent work has…
Citation impact
- FWCI
- 12.42
- Percentile
- 100%
- References
- 197
Authors
3Topics & keywords
- Biology
- Protein tyrosine phosphatase
- Signal transduction
- Cell biology
- Phosphorylation
- Receptor tyrosine kinase
- Phosphatase
- Regulator