Global Epigenomic Reconfiguration During Mammalian Brain Development

Lister, Ryan; Mukamel, Eran A.; Nery, Joseph R.; Urich, Mark A.; Puddifoot, Clare A.; Johnson, Nicholas D.; Lucero, Jacinta; Huang, Yun; Dwork, Andrew J.; Schultz, Matthew D.; Yu, Miao; Tonti‐Filippini, Julian; Heyn, Holger; Hu, Shijun; Wu, Joseph C.; Rao, Anjana; Esteller, Manel; He, Chuan; Haghighi, Fatemeh; Sejnowski, Terrence J.; Behrens, M. Margarita; Ecker, Joseph R.

doi:10.1126/science.1237905

articleScienceJul 5, 2013GREEN OA

Global Epigenomic Reconfiguration During Mammalian Brain Development

RLRyan Lister EAEran A. Mukamel JRJoseph R. Nery MAMark A. Urich CAClare A. Puddifoot

Salk Institute for Biological Studies · ARC Centre of Excellence in Plant Energy Biology · +10 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base…

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Topics & keywords

Topics

Keywords

Epigenetics
DNA methylation
Epigenomics
Biology
Epigenesis
Neuroscience
Brain development
Computational biology

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