Dynamic Coding for Cognitive Control in Prefrontal Cortex
University of Oxford · Wellcome Centre for Integrative Neuroimaging · +4 more institutions
Abstract
Cognitive flexibility is fundamental to adaptive intelligent behavior. Prefrontal cortex has long been associated with flexible cognitive function, but the neurophysiological principles that enable prefrontal cells to adapt their response properties according to context-dependent rules remain poorly understood. Here, we use time-resolved population-level neural pattern analyses to explore how context is encoded and maintained in primate prefrontal cortex and used in flexible decision making. We show that an instruction cue triggers a rapid series of state transitions before settling into a stable low-activity state. The postcue state is differentially tuned according to the current task-relevant rule. During…
Citation impact
- FWCI
- 26.01
- Percentile
- 100%
- References
- 53
Authors
6- MGMark G. StokesCorresponding
University of Oxford, Wellcome Centre for Integrative Neuroimaging
- MKMakoto Kusunoki
MRC Cognition and Brain Sciences Unit, University of Cambridge, University of Oxford
- NSNatasha Sigala
Brighton and Sussex Medical School, University of Sussex
- HNHamed Nili
MRC Cognition and Brain Sciences Unit, University of Cambridge
- DGDavid Gaffan
University of Oxford
Topics & keywords
- Prefrontal cortex
- Neuroscience
- Cognitive flexibility
- Neurophysiology
- Cognition
- Psychology
- Stimulus (psychology)
- Population
- Peace, Justice and strong institutions