Pericytes and the Pathogenesis of Diabetic Retinopathy
Heidelberg University · University Hospital Heidelberg · +5 more institutions
Abstract
Pericytes provide vascular stability and control endothelial proliferation. Pericyte loss, microaneurysms, and acellular capillaries are characteristic for the diabetic retina. Platelet-derived growth factor (PDGF)-B is involved in pericyte recruitment, and brain capillaries of mice with a genetic ablation of PDGF-B show pericyte loss and microaneurysms. We investigated the role of capillary coverage with pericytes in early diabetic retinopathy and the contribution to proliferative retinopathy using mice with a single functional allele of PDGF-B (PDGF-B(+/-) mice). As assessed by quantitative morphometry of retinal digest preparations, pericyte numbers in nondiabetic PDGF-B(+/-) mice were reduced by 30%…
Citation impact
- FWCI
- 13.57
- Percentile
- 100%
- References
- 36
Authors
8- HHHans-Peter HammesCorresponding
Heidelberg University, University Hospital Heidelberg, University Medical Centre Mannheim
- JLJihong Lin
Heidelberg University, University Hospital Heidelberg, University Medical Centre Mannheim
- OROliver Renner
Spanish National Cancer Research Centre
- MSMoshe Shani
Agricultural Research Organization
- ALAndrea Lundqvist
University of Gothenburg
Topics & keywords
- Pericyte
- Diabetic retinopathy
- Endocrinology
- Platelet-derived growth factor
- Angiogenesis
- Internal medicine
- Retinal
- Pathogenesis
- Good health and well-being