Determinants of BRAF Mutations in Primary Melanomas
University of California, San Francisco · Memorial Sloan Kettering Cancer Center · +1 more institution
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Abstract
The RAS/mitogen-activated protein kinase pathway sends external growth-promoting signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently activated by somatic mutation in melanoma. Using a cohort of 115 patients with primary invasive melanomas, we show that BRAF mutations are statistically significantly more common in melanomas occurring on skin subject to intermittent sun exposure than elsewhere (23 of 43 patients; P
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10Topics & keywords
Topics
Keywords
- Melanoma
- Mutation
- Cancer research
- Allele
- Biology
- Phenotype
- Chromosome
- Medicine
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