Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection
University of Pittsburgh · University of Vermont · +11 more institutions
Abstract
BACKGROUND: In the Strategies for Management of Anti-Retroviral Therapy trial, all-cause mortality was higher for participants randomized to intermittent, CD4-guided antiretroviral treatment (ART) (drug conservation [DC]) than continuous ART (viral suppression [VS]).We hypothesized that increased HIV-RNA levels following ART interruption induced activation of tissue factor pathways, thrombosis, and fibrinolysis. METHODS AND FINDINGS: Stored samples were used to measure six biomarkers: high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), amyloid A, amyloid P, D-dimer, and prothrombin fragment 1+2. Two studies were conducted: (1) a nested case-control study for studying biomarker associations with…
Citation impact
- FWCI
- 75.73
- Percentile
- 100%
- References
- 42
Authors
13- LHLewis H. KullerCorresponding
University of Pittsburgh
- RPRussell P. TracyCorresponding
University of Vermont
- WBWaldo BellosoCorresponding
Hospital Italiano de Buenos Aires
- SDStéphane De WitCorresponding
Centre Hospitalier Universitaire de Saint-Pierre
- FDFraser DrummondCorresponding
National Centre for Clinical Research on Emerging Drugs, UNSW Sydney
Topics & keywords
- Medicine
- Internal medicine
- Biomarker
- Odds ratio
- Confidence interval
- Quartile
- Gastroenterology
- C-reactive protein
- Good health and well-being