Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
University of Maryland, Baltimore · University of Wisconsin–Madison
Abstract
We present the complete genome sequence of uropathogenic Escherichia coli, strain CFT073. A three-way genome comparison of the CFT073, enterohemorrhagic E. coli EDL933, and laboratory strain MG1655 reveals that, amazingly, only 39.2% of their combined (nonredundant) set of proteins actually are common to all three strains. The pathogen genomes are as different from each other as each pathogen is from the benign strain. The difference in disease potential between O157:H7 and CFT073 is reflected in the absence of genes for type III secretion system or phage- and plasmid-encoded toxins found in some classes of diarrheagenic E. coli. The CFT073 genome is particularly rich in genes that encode potential fimbrial…
Citation impact
- FWCI
- 44.87
- Percentile
- 100%
- References
- 32
Authors
19- RARodney A. WelchCorresponding
University of Maryland, Baltimore, University of Wisconsin–Madison
- VBValerie Burland
University of Maryland, Baltimore, University of Wisconsin–Madison
- GPGuy Plunkett
University of Maryland, Baltimore, University of Wisconsin–Madison
- PRPeter Redford
University of Maryland, Baltimore, University of Wisconsin–Madison
- PRP. Roesch
University of Maryland, Baltimore, University of Wisconsin–Madison
Topics & keywords
- Escherichia coli
- Biology
- Genome
- Plasmid
- Synteny
- Pathogenicity island
- Gene
- Whole genome sequencing
- Life below water