TNF-α in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss the role of TNF-a in cancer survival and apoptosis.Describe the mechanism of chemotherapy potentiation by TNF-a.Explain the selective targeting of tumor vasculature by TNF-a.Discuss TNFR-1 and TNFR-2 signaling. Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com Tumor necrosis factor alpha (TNF-α), isolated 30 years ago, is a multifunctional cytokine playing a key role in apoptosis and cell survival as well as in inflammation and immunity. Although named for its antitumor properties, TNF has been implicated in a wide spectrum of other diseases. The current use of TNF…