Unique Clinicopathologic Features Characterize ALK -Rearranged Lung Adenocarcinoma in the Western Population
Brigham and Women's Hospital · University of Pittsburgh · +2 more institutions
Abstract
PURPOSE: The anaplastic large cell kinase gene (ALK) is rearranged in approximately 5% of lung adenocarcinomas within the Asian population. We evaluated the incidence and the characteristics of ALK-rearranged lung adenocarcinomas within the western population and the optimal diagnostic modality to detect ALK rearrangements in routine clinical practice. EXPERIMENTAL DESIGN: We tested 358 lung adenocarcinomas from three institutions for ALK rearrangements by fluorescent in situ hybridization (FISH) and immunohistochemistry with and without tyramide amplification. The clinicopathologic characteristics of tumors with and without ALK rearrangements were compared. RESULTS: We identified 20 (5.6%) lung…
Citation impact
- FWCI
- 39.69
- Percentile
- 100%
- References
- 54
Authors
15- SJScott J. Rodig
Brigham and Women's Hospital, University of Pittsburgh, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center
- MMMari Mino–Kenudson
Brigham and Women's Hospital, University of Pittsburgh, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center
- SĐSanja Đačić
Brigham and Women's Hospital, University of Pittsburgh, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center
- BYBeow Y. Yeap
Brigham and Women's Hospital, University of Pittsburgh, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center
- ATAlice T. Shaw
Brigham and Women's Hospital, University of Pittsburgh, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center
Topics & keywords
- Anaplastic lymphoma kinase
- Immunohistochemistry
- Gene rearrangement
- Adenocarcinoma
- Population
- Pathology
- Crizotinib
- Lung cancer
- Good health and well-being