reviewAnnual Review of BiochemistryMar 18, 2015BRONZE OA

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

YLYeon LeeDCDonald C. Rio

University of California, Berkeley

PubMed
Indexed incrossrefpubmed

Abstract

Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional regulation of gene expression, providing significant expansion of the functional proteome of eukaryotic organisms with limited gene numbers. Split eukaryotic genes contain intervening sequences or introns disrupting protein-coding exons, and intron removal occurs by repeated assembly of a large and highly dynamic ribonucleoprotein complex termed the spliceosome, which is composed of five small nuclear ribonucleoprotein particles, U1, U2, U4/U6, and U5. Biochemical studies over the past 10 years have allowed the isolation as well as compositional, functional, and structural analysis of splicing complexes at distinct stages…

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1,326
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Authors

2

Topics & keywords

Topics
Keywords
  • Spliceosome
  • RNA splicing
  • Intron
  • Exonic splicing enhancer
  • Biology
  • Genetics
  • Ribonucleoprotein
  • Minigene
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