Dynamics of Gray Matter Loss in Alzheimer's Disease

Thompson, Paul M.; Hayashi, Kiralee M.; Zubicaray, Greig I. de; Janke, Andrew L.; Rose, Stephen; Semple, James; Herman, David; Hong, Michael; Dittmer, Stephanie S.; Doddrell, David M.; Toga, Arthur W.

doi:10.1523/jneurosci.23-03-00994.2003

articleJournal of NeuroscienceFeb 1, 2003BRONZE OA

Dynamics of Gray Matter Loss in Alzheimer's Disease

PMPaul M. Thompson KMKiralee M. Hayashi GIGreig I. de Zubicaray ALAndrew L. Janke SRStephen Rose

University of California, Los Angeles · The University of Queensland · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD). The loss pattern was visualized in four dimensions as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor cortices. The shifting deficits were asymmetric (left hemisphere > right hemisphere) and correlated with progressively declining cognitive status (p 15% loss). The maps distinguished different phases of AD and differentiated AD from normal aging. Local gray matter loss rates (5.3 +/- 2.3% per year in AD v 0.9 +/- 0.9% per year in controls) were faster in the left hemisphere (p

Citation impact

1,139

total citations

FWCI: 20.03
Percentile: 100%
References: 107

Citations per year

Authors

11

Topics & keywords

Topics

Keywords

Atrophy
Neuroscience
Magnetic resonance imaging
White matter
Lateralization of brain function
Alzheimer's disease
Temporal lobe
Psychology

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.