Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab
The University of Texas MD Anderson Cancer Center · Piedmont Atlanta Hospital · +4 more institutions
Abstract
BACKGROUND: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab. METHODS AND RESULTS: Eighty-one women with newly diagnosed human epidermal growth factor receptor 2-positive breast cancer, treated with anthracyclines followed by taxanes and trastuzumab were enrolled to be evaluated every 3 months during their cancer therapy (total of 15 months) using echocardiograms and blood samples. Left ventricular ejection…
Citation impact
- FWCI
- 28.96
- Percentile
- 100%
- References
- 26
Authors
17- HSHeloisa SawayaCorresponding
The University of Texas MD Anderson Cancer Center, Piedmont Atlanta Hospital, Jewish General Hospital, Center for Cancer Research, McGill University, University of Pennsylvania
- IAIgal A. Sebag
The University of Texas MD Anderson Cancer Center, Piedmont Atlanta Hospital, Jewish General Hospital, Center for Cancer Research, McGill University, University of Pennsylvania
- JCJuan Carlos Plana
The University of Texas MD Anderson Cancer Center, Piedmont Atlanta Hospital, Jewish General Hospital, Center for Cancer Research, McGill University, University of Pennsylvania
- JLJames L. Januzzi
The University of Texas MD Anderson Cancer Center, Piedmont Atlanta Hospital, Jewish General Hospital, Center for Cancer Research, McGill University, University of Pennsylvania
- BKBonnie Ky
The University of Texas MD Anderson Cancer Center, Piedmont Atlanta Hospital, Jewish General Hospital, Center for Cancer Research, McGill University, University of Pennsylvania
Topics & keywords
- Medicine
- Trastuzumab
- Cardiotoxicity
- Ejection fraction
- Internal medicine
- Cardiology
- Natriuretic peptide
- Heart failure
- Good health and well-being