Base Excision Repair
Norwegian University of Science and Technology · Oslo University Hospital
Abstract
Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses different proteins to complete BER. At least 11 distinct mammalian DNA glycosylases are known, each recognizing a few related lesions, frequently with some overlap in specificities. Impressively, the damaged bases are rapidly identified in a vast excess of normal bases, without a supply of energy. BER protects against cancer, aging, and neurodegeneration and…
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Authors
2Topics & keywords
- DNA glycosylase
- Base excision repair
- AP site
- Biology
- Uracil-DNA glycosylase
- DNA repair
- Nucleotide excision repair
- DNA