Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat
Lahey Hospital and Medical Center · Hebrew University of Jerusalem · +4 more institutions
Abstract
Although plasmid-mediated quinolone resistance (PMQR) was thought not to exist before its discovery in 1998, the past decade has seen an explosion of research characterizing this phenomenon. The best-described form of PMQR is determined by the qnr group of genes. These genes, likely originating in aquatic organisms, code for pentapeptide repeat proteins. These proteins reduce susceptibility to quinolones by protecting the complex of DNA and DNA gyrase or topoisomerase IV enzymes from the inhibitory effect of quinolones. Two additional PMQR mechanisms were recently described. aac(6')-Ib-cr encodes a variant aminoglycoside acetyltransferase with two amino acid alterations allowing it to inactivate ciprofloxacin…
Citation impact
- FWCI
- 23.70
- Percentile
- 100%
- References
- 228
Authors
4- JSJacob StrahilevitzCorresponding
Lahey Hospital and Medical Center, Hebrew University of Jerusalem
- GAGeorge A. Jacoby
Lahey Hospital and Medical Center, Harvard University, Massachusetts General Hospital
- DCDavid C. Hooper
NorthShore University HealthSystem, Harvard University, University of Chicago, Massachusetts General Hospital
- ARAri Robicsek
NorthShore University HealthSystem, University of Chicago
Topics & keywords
- Topoisomerase IV
- DNA gyrase
- Quinolone
- Biology
- Plasmid
- Gene
- Efflux
- Microbiology