Cortical Folding Patterns and Predicting Cytoarchitecture
Harvard University · Massachusetts Institute of Technology · +6 more institutions
Abstract
The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations of the BAs, little is understood regarding 1) how variable the position of a given BA is with respect to the folds, 2) whether the location of some BAs is more variable than others, and 3) whether the variability is related to the level of a BA in a putative cortical hierarchy. We use whole-brain histology of 10 postmortem human brains and surface-based analysis to test how well the folds predict the locations of the BAs. We show that higher order cortical areas exhibit more variability than…
Citation impact
- FWCI
- 10.75
- Percentile
- 100%
- References
- 56
Authors
9- BFBruce FischlCorresponding
Harvard University, Massachusetts Institute of Technology
- NRNiranjini Rajendran
Medical University of the Americas, Harvard University
- EBEvelina Busa
Medical University of the Americas, Harvard University
- JCJean C. Augustinack
Harvard University, Medical University of the Americas
- OHOliver Hinds
McGovern Institute for Brain Research, Massachusetts Institute of Technology
Topics & keywords
- Cytoarchitecture
- Cerebral cortex
- Neuroscience
- Human brain
- Biology
- Folding (DSP implementation)
- Anatomy
Funding
- DFDeutsche Forschungsgemeinschaft
- NINational Institutes of HealthAwards: RR16594, U54 EB005149, U24 RR021382, EB005149, BIRN002, P41-RR14075, R01EB006758, RR14075
- NINational Institute of Mental Health
- NCNational Center for Research ResourcesAwards: BIRN002, U24 RR021382, R01 RR16594, RR14075, P41-RR14075, BIRN002, R01 RR16594-01A1, U24 RR021382