Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
University of California, Los Angeles · University of California System · +3 more institutions
Abstract
Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications. We review current approaches to the synthesis, solubilization, and functionalization of qdots and their applications to cell and animal biology. Recent examples of their experimental use include the observation of diffusion of individual glycine receptors in living neurons and the identification of lymph nodes in live animals by near-infrared emission during surgery. The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular…
Citation impact
- FWCI
- 237.38
- Percentile
- 100%
- References
- 81
Authors
10- XMXavier MichaletCorresponding
University of California, Los Angeles, University of California System, Stanford Medicine, Institute for Molecular Medicine, Stanford University
- FPFabien PinaudCorresponding
University of California, Los Angeles, University of California System, Stanford Medicine, Institute for Molecular Medicine, Stanford University
- LALaurent A. Bentolila
University of California, Los Angeles, University of California System, Stanford Medicine, Institute for Molecular Medicine, Stanford University
- JMJames M. Tsay
University of California, Los Angeles, University of California System, Stanford Medicine, Institute for Molecular Medicine, Stanford University
- SDSören DooseCorresponding
University of California, Los Angeles, University of California System, Stanford Medicine, Institute for Molecular Medicine, Stanford University
Topics & keywords
- Quantum dot
- Nanotechnology
- In vivo
- Fluorescence-lifetime imaging microscopy
- Live cell imaging
- Intracellular
- Preclinical imaging
- Materials science