The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
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Abstract
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human…
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307Topics & keywords
Topics
Keywords
- Biology
- Genome
- Gene
- Monotreme
- Genetics
- Evolutionary biology
- Whole genome sequencing
- Marsupial
UN Sustainable Development Goals
- Zero hunger
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