Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus
Okayama Prefectural University · Cardiovascular Institute of the South
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Abstract
BACKGROUND: An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM. METHODS AND RESULTS: Male Sprague-Dawley rats were fed normal chow or high-fat diet (n=5 in each) with moderate streptozotocin injection to induce type 2 DM. Plasma ADMA was elevated in diabetic rats (1.33+/-0.31 versus 0.48+/-0.08 micromol/L; P
Citation impact
656
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- FWCI
- 18.23
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- 100%
- References
- 44
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Authors
9Topics & keywords
Topics
Keywords
- Asymmetric dimethylarginine
- Internal medicine
- Endocrinology
- Nitric oxide
- Medicine
- Endothelial dysfunction
- Diabetes mellitus
- Nitric oxide synthase
UN Sustainable Development Goals
- Good health and well-being
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