ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
The University of Texas MD Anderson Cancer Center · The University of Texas Health Science Center at Houston · +5 more institutions
Abstract
Ataxia-telangiectasia mutated (ATM) is a cellular damage sensor that coordinates the cell cycle with damage-response checkpoints and DNA repair to preserve genomic integrity. However, ATM also has been implicated in metabolic regulation, and ATM deficiency is associated with elevated reactive oxygen species (ROS). ROS has a central role in many physiological and pathophysiological processes including inflammation and chronic diseases such as atherosclerosis and cancer, underscoring the importance of cellular pathways involved in redox homeostasis. We have identified a cytoplasmic function for ATM that participates in the cellular damage response to ROS. We show that in response to elevated ROS, ATM activates…
Citation impact
- FWCI
- 37.29
- Percentile
- 100%
- References
- 46
Authors
14- AAAngela Alexander
The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston
- SCSheng-Li Cai
The University of Texas MD Anderson Cancer Center
- JKJinhee Kim
The University of Texas MD Anderson Cancer Center
- ANAdrian Nañez
The University of Texas MD Anderson Cancer Center
- MŞMustafa Şahin
Boston Children's Hospital, Harvard University
Topics & keywords
- mTORC1
- Cell biology
- Autophagy
- DNA damage
- Biology
- Signal transduction
- Cytoplasm
- Reactive oxygen species