TEER Measurement Techniques for In Vitro Barrier Model Systems
University of Central Florida · Cornell University
Abstract
Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted quantitative technique to measure the integrity of tight junction dynamics in cell culture models of endothelial and epithelial monolayers. TEER values are strong indicators of the integrity of the cellular barriers before they are evaluated for transport of drugs or chemicals. TEER measurements can be performed in real time without cell damage and generally are based on measuring ohmic resistance or measuring impedance across a wide spectrum of frequencies. The measurements for various cell types have been reported with commercially available measurement systems and also with custom-built microfluidic implementations. Some of…
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Authors
6Topics & keywords
- In vitro
- Computer science
- Biophysics
- Biological system
- Chemistry
- Biology
- Biochemistry
- Good health and well-being