Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system
University of Illinois Urbana-Champaign · University of Illinois System · +1 more institution
Abstract
Acute cognitive impairment (i.e., delirium) is common in elderly emergency department patients and frequently results from infections that are unrelated to the central nervous system. Since activation of the peripheral innate immune system induces brain microglia to produce inflammatory cytokines that are responsible for behavioral deficits, we investigated if aging exacerbated neuroinflammation and sickness behavior after peripheral injection of lipopolysaccharide (LPS). Microarray analysis revealed a transcriptional profile indicating the presence of primed or activated microglia and increased inflammation in the aged brain. Furthermore, aged mice had a unique gene expression profile in the brain after an…
Citation impact
- FWCI
- 17.65
- Percentile
- 100%
- References
- 57
Authors
7- JPJonathan P. GodboutCorresponding
University of Illinois Urbana-Champaign, University of Illinois System
- JCJ. Chen
University of Illinois Urbana-Champaign, Urbana University, University of Illinois System
- JAJ. Abraham
University of Illinois Urbana-Champaign, University of Illinois System
- AFAmy F. Richwine
University of Illinois Urbana-Champaign, Urbana University, University of Illinois System
- BBBrian Berg
University of Illinois Urbana-Champaign, University of Illinois System
Topics & keywords
- Neuroinflammation
- Sickness behavior
- Microglia
- Innate immune system
- Immunology
- Medicine
- Immune system
- Lipopolysaccharide
- Good health and well-being