Insulin sensitivity: modulation by nutrients and inflammation

Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms by which brief nutrient excess and obesity lead to insulin resistance and propose that these mechanisms of action are different but interrelated. We discuss how pathways that "sense" nutrients within skeletal muscle are readily able to regulate insulin action. We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. In particular, we focus on the hypothesis that the macrophage is an important cell type…

• AD
  American Diabetes Association
• P
  Pfizer
• NI
  National Institutes of Health
• NI
  National Institute of Child Health and Human Development
• EK
  Eunice Kennedy Shriver National Institute of Child Health and Human Development