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Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst
Gachon University · Seoul National University · +3 more institutions
Abstract
Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst. The SCNT-hES-1 cells displayed typical ES cell morphology and cell surface markers and were capable of differentiating into embryoid bodies in vitro and of forming teratomas in vivo containing cell derivatives from all three embryonic germ layers in severe combined immunodeficient mice. After continuous proliferation for more than 70 passages, SCNT-hES-1 cells maintained normal karyotypes and were genetically identical to the somatic nuclear donor cells.…
Citation impact
- FWCI
- 47.85
- Percentile
- 100%
- References
- 26
Authors
15- WSWoo Suk HwangCorresponding
Gachon University, Seoul National University, MizMedi Hospital
- YJYoung June Ryu
Gachon University, Seoul National University, MizMedi Hospital
- JHJong Hyuk Park
Gachon University, Seoul National University, MizMedi Hospital
- ESEul Soon Park
Gachon University, Seoul National University, MizMedi Hospital
- ELEugene Lee
Gachon University, Seoul National University, MizMedi Hospital
Topics & keywords
- Somatic cell nuclear transfer
- Embryoid body
- Blastocyst
- Embryonic stem cell
- Biology
- Induced pluripotent stem cell
- Somatic cell
- Cell biology