The Genome Sequence of Trypanosoma cruzi , Etiologic Agent of Chagas Disease

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of…

• GA
  Grantová Agentura, Univerzita Karlova
• JH
  Johns Hopkins University
• LS
  London School of Hygiene and Tropical Medicine
• WT
  Wellcome Trust
• EM
  European Molecular Biology Laboratory
• UO
  University of Oxford
• UO
  University of Glasgow
• CN
  Consejo Nacional de Investigaciones Científicas y Técnicas
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico
• KI
  Karolinska Institutet
• CN
  Centre National de la Recherche Scientifique
• UD
  Universidad de Buenos Aires

  Award: CONICET
• FO
  Fundação Oswaldo Cruz
• UU
  Uppsala Universitet
• UF
  Universidade Federal de Minas Gerais
• CC
  CYTED Ciencia y Tecnología para el Desarrollo
• UO
  University of California, Los Angeles

  Award: CONICET
• DO
  Department of Biochemistry, University of Cambridge
• NI
  National Institute of Allergy and Infectious Diseases