Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
National Institute of Science Education and Research · University of California San Diego · +1 more institution
Abstract
Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes involved in protecting cells from the damaging effects of ROS. ROS are produced in response to ultraviolet radiation, cigarette smoking, alcohol, nonsteroidal anti-inflammatory drugs, ischemia-reperfusion injury, chronic infections, and inflammatory disorders. Disruption of normal cellular homeostasis by redox signaling may result in cardiovascular, neurodegenerative diseases and cancer. ROS are produced within the gastrointestinal (GI) tract, but their roles in pathophysiology and disease pathogenesis have not been well studied. Despite…
Citation impact
- FWCI
- 41.11
- Percentile
- 100%
- References
- 349
Authors
4- ABAsima Bhattacharyya
National Institute of Science Education and Research, University of California San Diego, The University of Texas Medical Branch at Galveston
- RCRanajoy Chattopadhyay
National Institute of Science Education and Research, University of California San Diego, The University of Texas Medical Branch at Galveston
- SMSankar Mitra
National Institute of Science Education and Research, University of California San Diego, The University of Texas Medical Branch at Galveston
- SESheila E. CroweCorresponding
National Institute of Science Education and Research, University of California San Diego, The University of Texas Medical Branch at Galveston
Topics & keywords
- Oxidative stress
- Pathogenesis
- Superoxide dismutase
- Gastrointestinal epithelium
- Immunology
- Reactive oxygen species
- Inflammation
- Gastrointestinal tract
- Good health and well-being