Low-Grade Albuminuria and Incidence of Cardiovascular Disease Events in Nonhypertensive and Nondiabetic Individuals
Boston University · Brigham and Women's Hospital · +3 more institutions
Abstract
BACKGROUND: Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals. METHODS AND RESULTS: We examined the association of urinary albumin excretion (spot urine albumin indexed to creatinine [UACR]) and the incidence of CVD events and all-cause mortality in 1568 nonhypertensive, nondiabetic Framingham Offspring Study participants (mean age, 55 years; 58% women) free of CVD. On follow-up (median, 6 years), 54 participants (20 women) developed a first CVD event, and 49 (19 women) died. After adjustment for established risk factors, increasing UACR was associated…
Citation impact
- FWCI
- 20.12
- Percentile
- 100%
- References
- 52
Authors
9- JÄJohan ÄrnlövCorresponding
Boston University, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute
- JCJane C. Evans
Boston University, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute
- JBJames B. Meigs
Boston University, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute
- TJThomas J. Wang
Boston University, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute
- CSCaroline S. Fox
Boston University, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute
Topics & keywords
- Medicine
- Microalbuminuria
- Albuminuria
- Incidence (geometry)
- Internal medicine
- Creatinine
- Framingham Risk Score
- Proteinuria
- Good health and well-being