Macrophages are required for adult salamander limb regeneration

The failure to replace damaged body parts in adult mammals results from a muted growth response and fibrotic scarring. Although infiltrating immune cells play a major role in determining the variable outcome of mammalian wound repair, little is known about the modulation of immune cell signaling in efficiently regenerating species such as the salamander, which can regrow complete body structures as adults. Here we present a comprehensive analysis of immune signaling during limb regeneration in axolotl, an aquatic salamander, and reveal a temporally defined requirement for macrophage infiltration in the regenerative process. Although many features of mammalian cytokine/chemokine signaling are retained in the…

• AG
  Australian Government
• SC
  Stem Cells Australia
• SG
  State Government of Victoria
• MR
  Medical Research Council
• AR
  Australian Research Council
• NH
  National Health and Medical Research Council