The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
Instituto de Investigaciones Biomédicas Sols-Morreale · Universidad Autónoma de Madrid · +2 more institutions
Abstract
Transcriptional repression mechanisms have emerged as one of the crucial processes for the downregulation of E-cadherin expression during development and tumour progression. Recently, several E-cadherin transcriptional repressors have been characterized (Snail, E12/E47, ZEB-1 and SIP-1) and shown to act through an interaction with proximal E-boxes of the E-cadherin promoter. We have analyzed the participation of another member of the Snail family, Slug, and observed that it also behaves as a repressor of E-cadherin expression. Stable expression of Slug in MDCK cells leads to the full repression of E-cadherin at transcriptional level and triggers a complete epithelial to mesenchymal transition. Slug-induced…
Citation impact
- FWCI
- 8.17
- Percentile
- 100%
- References
- 48
Authors
6- VBVictoria Bolós
Instituto de Investigaciones Biomédicas Sols-Morreale, Universidad Autónoma de Madrid
- HPHéctor Peinado
Instituto de Investigaciones Biomédicas Sols-Morreale, Universidad Autónoma de Madrid
- MPMirna Pérez‐Moreno
Instituto de Investigaciones Biomédicas Sols-Morreale, Universidad Autónoma de Madrid, Rockefeller University
- MFMario F. Fraga
Spanish National Cancer Research Centre
- MEManel Esteller
Spanish National Cancer Research Centre
Topics & keywords
- Slug
- Repressor
- Biology
- Psychological repression
- Snail
- Cadherin
- Transcription factor
- Epithelial–mesenchymal transition