Selective neuronal vulnerability to oxidative stress in the brain

Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiological levels, an excessive amount of these molecules leads to oxidative modification and, therefore, dysfunction of proteins, nucleic acids, and lipids. The response of neurons to this pervasive stress, however, is not uniform in the brain. While many brain neurons can cope with a rise in OS, there are select populations of neurons in the brain that are vulnerable. Because of their selective…

• NI
  National Institute on Aging

  Award: AG12993
• NI
  National Institute of Child Health and Human Development

  Award: HD02528
• NC
  National Center for Research Resources

  Award: HD02528
• EK
  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  Award: HD02528