Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

The study of the potential risks associated with the manufacture, use, and disposal of nanoscale materials, and their mechanisms of toxicity, is important for the continued advancement of nanotechnology. Currently, the most widely accepted paradigms of nanomaterial toxicity are oxidative stress and inflammation, but the underlying mechanisms are poorly defined. This review will highlight the significance of autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Most endocytic routes of nanomaterial cell uptake converge upon the lysosome, making the lysosomal compartment the most common intracellular site of nanoparticle sequestration and degradation. In addition to the…

• UD
  U.S. Department of Health and Human Services

  Award: HHSN261200800001E
• NI
  National Institutes of Health

  Awards: Contract No. HHSN261200800001E, HHSN261200800001E
• NC
  National Cancer Institute

  Awards: No. HHSN261200800001E, Contract No. HHSN261200800001E