Commensal bacteria protect against food allergen sensitization
Columbia University Irving Medical Center · University of Chicago · +6 more institutions
Abstract
Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the…
Citation impact
- FWCI
- 28.36
- Percentile
- 100%
- References
- 39
Authors
15- ASAndrew Stefka
Columbia University Irving Medical Center, University of Chicago, Apath (United States), New York University
- TFTaylor Feehley
Columbia University Irving Medical Center, University of Chicago, Apath (United States), New York University
- PTPrabhanshu Tripathi
Columbia University Irving Medical Center, University of Chicago, Apath (United States), New York University
- JQJu Qiu
Northwestern University
- KDKathy D. McCoy
University of Bern
Topics & keywords
- Sensitization
- Food allergy
- Clostridia
- Allergen
- Microbiology
- Immunology
- Biology
- Allergy
- Zero hunger