Immunosuppressive Strategies that are Mediated by Tumor Cells

Despite major advances in understanding the mechanisms leading to tumor immunity, a number of obstacles hinder the successful translation of mechanistic insights into effective tumor immunotherapy. Such obstacles include the ability of tumors to foster a tolerant microenvironment and the activation of a plethora of immunosuppressive mechanisms, which may act in concert to counteract effective immune responses. Here we discuss different strategies employed by tumors to thwart immune responses, including tumor-induced impairment of antigen presentation, the activation of negative costimulatory signals, and the elaboration of immunosuppressive factors. In addition, we underscore the influence of regulatory cell…

• CR
  Cancer Research Institute
• FF
  Fundación Florencio Fiorini
• MF
  Mizutani Foundation for Glycoscience
• FS
  Fundación Sales
• CN
  Consejo Nacional de Investigaciones Científicas y Técnicas
• UD
  Universidad de Buenos Aires

  Award: CONICET