NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
The University of Sydney · Millennium Institute · +3 more institutions
Abstract
Nonalcoholic steatohepatitis (NASH) is often linked with disorders that are clearly associated with insulin resistance (IR): obesity, type 2 diabetes mellitus, and hypertriglyceridemia. We tested the hypotheses that (1) IR is an essential requirement for the development of NASH and (2) a high association between IR and liver disease is relatively specific for NASH. We measured body mass index (BMI), waist/hip ratio, and fasting serum lipid, insulin, C-peptide, and glucose levels in 66 patients with NASH (21 with advanced fibrosis and 45 with mild fibrosis). IR was determined by the homeostasis model assessment (HOMA). We also determined the strength of the association of NASH with insulin resistance syndrome…
Citation impact
- FWCI
- 43.36
- Percentile
- 100%
- References
- 39
Authors
12- SCShivakumar Chitturi
The University of Sydney, Millennium Institute, Westmead Hospital, Westmead Institute
- SAShehan Abeygunasekera
Nepean Hospital
- GCGeoffrey C. Farrell
The University of Sydney, Westmead Hospital, Westmead Institute
- JHJANE HOLMES-WALKER
Westmead Hospital
- JMJason M. Hui
The University of Sydney, Westmead Hospital, Westmead Institute
Topics & keywords
- Insulin resistance
- Internal medicine
- Hyperinsulinemia
- Medicine
- Endocrinology
- Insulin
- Homeostatic model assessment
- Body mass index
- Good health and well-being