Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers
Albert Einstein College of Medicine · Memorial Sloan Kettering Cancer Center · +2 more institutions
Abstract
UNLABELLED: We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA repair genes that promotes prostate cancer radioresistance, providing a potential mechanism by which androgen deprivation therapy synergizes with ionizing radiation. Using a model of castration-resistant prostate cancer, we show that second-generation antiandrogen therapy results in downregulation of DNA repair genes. Next, we demonstrate that primary prostate cancers display a significant spectrum of AR transcriptional output, which correlates with expression of a set of DNA repair genes. Using RNA-seq and ChIP-seq, we define which of these DNA repair genes are both induced by androgen and represent direct AR…
Citation impact
- FWCI
- 17.60
- Percentile
- 100%
- References
- 30
Authors
25- WRWilliam R. Polkinghorn
Albert Einstein College of Medicine, Memorial Sloan Kettering Cancer Center, UNC Lineberger Comprehensive Cancer Center
- JSJoel S. Parker
Albert Einstein College of Medicine, Memorial Sloan Kettering Cancer Center, UNC Lineberger Comprehensive Cancer Center
- MXMan X. Lee
University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, Memorial Sloan Kettering Cancer Center, UNC Lineberger Comprehensive Cancer Center
- EMElizabeth M. Kass
University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, Memorial Sloan Kettering Cancer Center, UNC Lineberger Comprehensive Cancer Center
- DEDaniel E. Spratt
University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, Memorial Sloan Kettering Cancer Center, UNC Lineberger Comprehensive Cancer Center
Topics & keywords
- Androgen receptor
- Prostate cancer
- Cancer research
- DNA repair
- Prostate
- Signal transduction
- DNA
- Receptor
- Good health and well-being