Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
Brigham and Women's Hospital · Harvard University · +2 more institutions
Abstract
Self-resolving inflammatory exudates and lipid mediator metabolomics recently uncovered a new family of potent anti-inflammatory and proresolving mediators biosynthesized by macrophages (MΦs), denoted maresins. Here we determined that maresin 1 (MaR1) produced by human MΦs from endogenous docosahexaenoic acid (DHA) matched synthetic 7R,14S-dihydroxydocosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid. The MaR1 alcohol groups and Z/E geometry of conjugated double bonds were matched using isomers prepared by total organic synthesis. MaR1's potent defining actions were confirmed with synthetic MaR1, i.e., limiting polymorphonuclear neutrophil (PMN) infiltration in murine peritonitis (ng/mouse range) as well as enhancing…
Citation impact
- FWCI
- 84.02
- Percentile
- 100%
- References
- 51
Authors
9- CNCharles N. SerhanCorresponding
Brigham and Women's Hospital, Harvard University, Center for Systems Biology
- JDJesmond Dalli
Brigham and Women's Hospital, Harvard University, Center for Systems Biology
- SKSergey Karamnov
Brigham and Women's Hospital, Harvard University, Center for Systems Biology
- AJAlexander J. Choi
Brigham and Women's Hospital, Harvard University, Center for Systems Biology
- CPChul‐Kyu Park
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Mediator
- Regeneration (biology)
- Macrophage
- Inflammatory mediator
- Chemistry
- Inflammation
- Cell biology
- Medicine