Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Evans, David M.; Spencer, Chris C. A.; Pointon, Jennifer J.; Su, Zhan; Harvey, David; Kochan, Grazyna; Oppermann, Udo; Dilthey, Alexander; Pirinen, Matti; Stone, Millicent; Appleton, Louise; Moutsianas, Loukas; Leslie, Stephen; Wordsworth, Tom; Kenna, Tony; Karaderi, Tugce; Thomas, Gethin; Ward, Michael M.; Weisman, Michael H.; Farrar, Claire; Bradbury, Linda A.; Danoy, Patrick; Inman, Robert D.; Maksymowych, Walter P.; Gladman, Dafna; Rahman, Proton; Morgan, Ann W; Marzo-Ortega, Helena; Bowness, Paul; Gaffney, Karl; Gaston, J. S. Hill; Smith, Malcolm; Bruges‐Armas, Jácome; Couto, Ana Rita; Sorrentino, Rosa; Paladini, Fabiana; Ferreira, Manuel A. R.; Xu, Huji; Liu, Yu; Jiang, Lei; López‐Larrea, Carlos; Díaz‐Peña, Roberto; López‐Vázquez, Antonio; Zayats, Tetyana; Band, Gavin; Bellenguez, Céline; Blackburn, Hannah; Blackwell, Jenefer M.; Bramon, Elvira; Bumpstead, Suzannah J.; Casas, Juan Pablo; Corvin, Aiden; Craddock, Nicholas; Deloukas, Panos; Dronov, Serge; Duncanson, Audrey; Edkins, Sarah; Freeman, Colin; Gillman, Matthew; Gray, Emma; Gwilliam, Rhian; Hammond, Naomi; Hunt, Sarah; Jankowski, Janusz; Jayakumar, Alagurevathi; Langford, Cordelia; Liddle, Jennifer; Markus, Hugh S.; Mathew, Christopher G.; McCann, Owen T; McCarthy, Mark I.; Palmer, Colin N A; Peltonen, Leena; Plomin, Robert; Potter, Simon; Rautanen, Anna; Ravindrarajah, Rathi; Ricketts, Michelle; Samani, Nilesh J.; Sawcer, Stephen; Strange, Amy; Trembath, Richard C.; Viswanathan, Ananth C.; Waller, Matthew; Weston, Paul A.; Whittaker, Pamela; Widaa, Sara; Wood, Nicholas; McVean, Gil; Reveille, John D.; Wordsworth, B P; Brown, Matthew A.; Donnelly, Peter

doi:10.1038/ng.873

articleNature GeneticsJul 10, 2011BRONZE OA

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

DMDavid M. Evans CCChris C. A. Spencer JJJennifer J. Pointon ZSZhan Su DHDavid Harvey

University of Bristol · Medical Research Council · +44 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

904

total citations

FWCI: 51.69
Percentile: 100%
References: 56

Citations per year

Authors

DM
David M. EvansCorresponding
University of Bristol, Medical Research Council
CC
Chris C. A. Spencer
Centre for Human Genetics, University of Oxford
JJ
Jennifer J. Pointon
National Institute for Health Research, Nuffield Orthopaedic Centre
ZS
Zhan Su
Centre for Human Genetics, University of Oxford
DH
David Harvey
National Institute for Health Research, Nuffield Orthopaedic Centre

Topics & keywords

Topics

Spondyloarthritis Studies and Treatments100%
Rheumatoid Arthritis Research and Therapies100%
Psoriasis: Treatment and Pathogenesis100%

Keywords

Ankylosing spondylitis
HLA-B27
Human leukocyte antigen
Biology
Immunology
Disease
Mechanism (biology)
Spondylitis

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

G
GlaxoSmithKline
OI
Ontario Innovation Trust
GC
Genome Canada
WT
Wellcome Trust
Awards: 068545/Z/02, G0000934, 1097737, 076113
CM
Cedars-Sinai Medical Center
OG
Ontario Genomics
OG
Ontario Genomics Institute
AS
Arthritis Society
NI
National Institute for Health and Care Research
AC
Australian Cancer Research Foundation
SF
Stiftelsen för Strategisk Forskning
UD
Università di Cagliari
KI
Karolinska Institutet
KO
Knut och Alice Wallenbergs Stiftelse
LM
Lions Medical Research Foundation
NI
National Institutes of Health
Awards: G0000934, MO1-RR00425, 068545/Z/02, RR00425
MR
Medical Research Council
Awards: 068545/Z/02, G0000934
NH
National Health and Medical Research Council
Awards: 569829, 566938, G0000934
NI
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: P01-052915, R01-AR046208