articleClinical Infectious DiseasesApr 20, 2004Closed access

Trends in Antimicrobial Drug Development: Implications for the Future

BSBrad SpellbergJHJohn H. PowersEPEric P. BrassLGLoren G. MillerJEJohn E. Edwards

UCLA Medical Center · Los Angeles Biomedical Research Institute

PubMed
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Abstract

The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens, the rapid emergence of new infections, and the potential for use of multidrug-resistant agents in bioweapons. Paradoxically, some pharmaceutical companies have indicated that they are curtailing anti-infective research programs. We evaluated the United States Food and Drug Administration (FDA) databases of approved drugs and the research and development programs of the world's largest pharmaceutical and biotechnology companies to document trends in the development of new antimicrobial agents. FDA approval of new antibacterial agents decreased by 56% over the past 20 years (1998-2002…

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863
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5

Topics & keywords

Topics
Keywords
  • Antimicrobial
  • Medicine
  • Antimicrobial drug
  • Drug development
  • Drug
  • Anti-Infective Agents
  • Food and drug administration
  • Biotechnology
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