Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease
The University of Melbourne · University of California, San Francisco · +1 more institution
Abstract
The tachykinins, exemplified by substance P, are one of the most intensively studied neuropeptide families. They comprise a series of structurally related peptides that derive from alternate processing of three Tac genes and are expressed throughout the nervous and immune systems. Tachykinins interact with three neurokinin G protein-coupled receptors. The signaling, trafficking, and regulation of neurokinin receptors have also been topics of intense study. Tachykinins participate in important physiological processes in the nervous, immune, gastrointestinal, respiratory, urogenital, and dermal systems, including inflammation, nociception, smooth muscle contractility, epithelial secretion, and proliferation.…
Citation impact
- FWCI
- 18.82
- Percentile
- 100%
- References
- 369
Authors
5- MSMartin SteinhoffCorresponding
The University of Melbourne, University of California, San Francisco, University of Florence
- BVBengt von Mentzer
The University of Melbourne, University of California, San Francisco, University of Florence
- PGPierangelo Geppetti
The University of Melbourne, University of California, San Francisco, University of Florence
- CPCharalabos Pothoulakis
The University of Melbourne, University of California, San Francisco, University of Florence
- NWNigel W. Bunnett
The University of Melbourne, University of California, San Francisco, University of Florence
Topics & keywords
- Neurokinin A
- Substance P
- Receptor
- Inflammation
- Immunology
- Medicine
- Biology
- Neuroscience
- Good health and well-being