Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy
National Institutes of Health · National Institute of Biomedical Imaging and Bioengineering · +2 more institutions
Abstract
The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG-b-PCL block-copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37%) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with…
Citation impact
- FWCI
- 31.79
- Percentile
- 100%
- References
- 41
Authors
13- PHPeng Huang
National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering
- JLJing Lin
University of Maryland, College Park
- WLWanwan Li
National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering
- PRPengfei Rong
National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering
- ZWZhe Wang
National Institutes of Health, Xiamen University, National Institute of Biomedical Imaging and Bioengineering
Topics & keywords
- Photothermal therapy
- Plasmon
- Materials science
- Nanotechnology
- Colloidal gold
- Surface plasmon resonance
- Photoacoustic imaging in biomedicine
- Nanoparticle
- Affordable and clean energy