Interactions between Sox9 and β-catenin control chondrocyte differentiation
The University of Texas MD Anderson Cancer Center · Laboratory of Molecular Genetics · +1 more institution
Abstract
Chondrogenesis is a multistep process that is essential for endochondral bone formation. Previous results have indicated a role for beta-catenin and Wnt signaling in this pathway. Here we show the existence of physical and functional interactions between beta-catenin and Sox9, a transcription factor that is required in successive steps of chondrogenesis. In vivo, either overexpression of Sox9 or inactivation of beta-catenin in chondrocytes of mouse embryos produces a similar phenotype of dwarfism with decreased chondrocyte proliferation, delayed hypertrophic chondrocyte differentiation, and endochondral bone formation. Furthermore, either inactivation of Sox9 or stabilization of beta-catenin in chondrocytes…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 56
Authors
12- HAHaruhiko AkiyamaCorresponding
The University of Texas MD Anderson Cancer Center, Laboratory of Molecular Genetics
- JPJon P. Lyons
The University of Texas MD Anderson Cancer Center, Kyoto University
- YMYuko Mori–Akiyama
Kyoto University, Laboratory of Molecular Genetics
- XYXiaohong Yang
Kyoto University, Laboratory of Molecular Genetics
- RZRen Zhang
The University of Texas MD Anderson Cancer Center, Kyoto University, Laboratory of Molecular Genetics
Topics & keywords
- SOX9
- Chondrogenesis
- Chondrocyte
- Wnt signaling pathway
- Biology
- Catenin
- Cell biology
- Transactivation