reviewPLoS GeneticsMar 10, 2011GOLD OA

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

EKElizabeth K. SpeliotesLMLaura M. Yerges‐ArmstrongJWJun WuRHRubén HernáezLJLauren J. Kim

Broad Institute · University of Michigan · +25 more institutions

PubMed
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Abstract

Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (∼26%-27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n = 880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ∼2.4 million imputed or genotyped SNPs in…

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Topics & keywords

Topics
Keywords
  • Biology
  • Genome-wide association study
  • Nonalcoholic fatty liver disease
  • Genetics
  • Genetic association
  • Fatty liver
  • Disease
  • Gene
UN Sustainable Development Goals
  • Good health and well-being
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