Human Papillomavirus Testing in the Prevention of Cervical Cancer
American Society for Clinical Pathology · Division of Cancer Epidemiology and Genetics · +3 more institutions
Abstract
Strong evidence now supports the adoption of cervical cancer prevention strategies that explicitly focus on persistent infection with the causal agent, human papillomavirus (HPV). To inform an evidence-based transition to a new public health approach for cervical cancer screening, we summarize the natural history and cervical carcinogenicity of HPV and discuss the promise and uncertainties of currently available screening methods. New HPV infections acquired at any age are virtually always benign, but persistent infections with one of approximately 12 carcinogenic HPV types explain virtually all cases of cervical cancer. In the absence of an overtly persistent HPV infection, the risk of cervical cancer is…
Citation impact
- FWCI
- 47.15
- Percentile
- 100%
- References
- 143
Authors
6- MSMark SchiffmanCorresponding
American Society for Clinical Pathology, Division of Cancer Epidemiology and Genetics, Kaiser Permanente, National Cancer Institute
- NWNicolas Wentzensen
National Cancer Institute, Division of Cancer Epidemiology and Genetics, American Society for Clinical Pathology, Kaiser Permanente, Westat (United States)
- SWSholom Wacholder
American Society for Clinical Pathology, Kaiser Permanente, Westat (United States), National Cancer Institute, Division of Cancer Epidemiology and Genetics
- WKWalter Kinney
Westat (United States), Kaiser Permanente, Division of Cancer Epidemiology and Genetics, National Cancer Institute, American Society for Clinical Pathology
- JCJulia C. Gage
Kaiser Permanente, Westat (United States), Division of Cancer Epidemiology and Genetics, American Society for Clinical Pathology, National Cancer Institute
Topics & keywords
- Cervical cancer
- Medicine
- Cervical intraepithelial neoplasia
- HPV infection
- Human papillomavirus
- Gynecology
- Colposcopy
- Cancer