Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
Institut d'Investigació Biomédica de Bellvitge · Christian-Albrechts-Universität zu Kiel · +14 more institutions
Abstract
Monozygotic (MZ) twins are partially concordant for most complex diseases, including autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, discordance suggests the role of non-genetic factors. In autoimmune diseases, environmentally driven epigenetic changes are thought to contribute to their etiology. Here we report the first high-throughput and candidate sequence analyses of DNA methylation to investigate discordance for autoimmune disease in twins. We used a cohort of MZ twins discordant for three diseases whose clinical signs often overlap: systemic lupus erythematosus (SLE), rheumatoid arthritis, and dermatomyositis. Only MZ twins discordant for SLE featured widespread…
Citation impact
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- References
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Authors
22- BMBiola M. Javierre
Institut d'Investigació Biomédica de Bellvitge
- AFAgustín F. Fernández
Institut d'Investigació Biomédica de Bellvitge
- JRJulia Richter
Christian-Albrechts-Universität zu Kiel, University Hospital Schleswig-Holstein, University of Lübeck
- FAFátima Al‐Shahrour
Broad Institute, Brigham and Women's Hospital, Harvard University, Centro de Investigacion Principe Felipe
- JIJosé I. Martín‐Subero
Christian-Albrechts-Universität zu Kiel, University Hospital Schleswig-Holstein, University of Lübeck
Topics & keywords
- DNA methylation
- Biology
- Epigenetics
- Immunology
- Monozygotic twin
- Autoimmune disease
- Concordance
- Genetics
- Life in Land