VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors
Délégation Paris 5 · Inserm · +8 more institutions
Abstract
Immune escape is a prerequisite for tumor development. To avoid the immune system, tumors develop different mechanisms, including T cell exhaustion, which is characterized by expression of immune inhibitory receptors, such as PD-1, CTLA-4, Tim-3, and a progressive loss of function. The recent development of therapies targeting PD-1 and CTLA-4 have raised great interest since they induced long-lasting objective responses in patients suffering from advanced metastatic tumors. However, the regulation of PD-1 expression, and thereby of exhaustion, is unclear. VEGF-A, a proangiogenic molecule produced by the tumors, plays a key role in the development of an immunosuppressive microenvironment. We report in the…
Citation impact
- FWCI
- 27.85
- Percentile
- 100%
- References
- 32
Authors
18- TVThibault Voron
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Service de la Santé Publique, Hôpital Européen Georges-Pompidou, Hôpital Européen, Paris Cardiovascular Research Center, Digestive Care (United States)
- OCOrianne Colussi
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Service de la Santé Publique, Hôpital Européen Georges-Pompidou, Hôpital Européen, Paris Cardiovascular Research Center, Digestive Care (United States)
- EMElie Marcheteau
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Paris Cardiovascular Research Center
- SPSimon Pernot
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Service de la Santé Publique, Hôpital Européen Georges-Pompidou, Hôpital Européen, Paris Cardiovascular Research Center, Digestive Care (United States)
- MNMevyn Nizard
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Paris Cardiovascular Research Center
Topics & keywords
- CD8
- Immune system
- Cancer research
- Tumor microenvironment
- Inhibitory postsynaptic potential
- Angiogenesis
- VEGF receptors
- Function (biology)
- Good health and well-being