Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

Ikonomović, Miloš D.; Klunk, William E.; Abrahamson, Eric E.; Mathis, Chester A.; Price, Julie C.; Tsopelas, Nicholas D.; Lopresti, Brian J.; Ziolko, Scott K.; Bi, Wenzhu; Paljug, William R.; Debnath, Manik L.; Hope, Caroline E.; Isanski, Barbara A.; Hamilton, Ronald L.; DeKosky, Steven T.

doi:10.1093/brain/awn016

articleBrainMar 12, 2008BRONZE OA

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

MDMiloš D. Ikonomović WEWilliam E. Klunk EEEric E. Abrahamson CAChester A. Mathis JCJulie C. Price

University of Pittsburgh

PubMed

Indexed incrossrefpubmed

Abstract

The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to beta-pleated sheet aggregates of the amyloid-beta (Abeta) peptide in vitro. The in vivo retention of PiB in brains of people with Alzheimer's disease shows a regional distribution that is very similar to distribution of Abeta deposits observed post-mortem. However, the basis for regional variations in PiB binding in vivo, and the extent to which it binds to different types of Abeta-containing plaques and tau-containing neurofibrillary tangles (NFT), has not been thoroughly investigated. The present study examined 28 clinically diagnosed and autopsy-confirmed Alzheimer's disease subjects, including one…

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Keywords

Pittsburgh compound B
In vivo
Pathology
Alzheimer's disease
Positron emission tomography
Senile plaques
Chemistry
Amyloid (mycology)

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